Publications.

Comparing microscopic and macroscopic diffusion in drug delivery: A study of small drug and protein dynamics in a supramolecular peptide hydrogel

Morbidini, R., Edkins, R.M., Carrascosa-Tejedor, J., Czakkel, O., Hanafy, B.I., Kalaria, D.R., Seydel, T., Edkins, K.

Journal of Colloid and Interface Science · 707, 139633 · 2026

Compares how small drugs and proteins diffuse at the molecular scale versus the bulk scale within an injectable peptide hydrogel, informing how such depots are designed to release a drug over time.

doi:10.1016/j.jcis.2025.139633

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Hanafy, B.I., Lu, C.-E., Liu, K., Gallud, A.

Advanced Functional Materials · 36(27), e25076 · 2025

The model behind the interactive profiler on this site. Predicts functional mRNA delivery across eight tissues from lipid composition and particle size.

doi:10.1002/adfm.202525076

Advancing Cellular-Specific Delivery: Machine Learning Insights into Lipid Nanoparticles Design and Cellular Tropism

Hanafy, B.I., Munson, M.J., Soundararajan, R., Pereira, S., Gallud, A., Sanaullah, S.M., Carlesso, G., Mazza, M.

Advanced Healthcare Materials · 14(18), 2500383 · 2025

Machine learning applied to a 180-formulation design of experiments, linking lipid chemistry to which immune cell type an LNP actually reaches.

doi:10.1002/adhm.202500383

Predicting human subcutaneous bioavailability of monoclonal antibodies using an integrated in-vitro/in-silico approach

Hanafy, B.I., Trayton, I., Sundqvist, M., Caldwell, J., Mody, N., Day, K., Mazza, M.

Journal of Controlled Release · 380, 715–724 · 2025

Predicts how much of a subcutaneously injected antibody reaches the bloodstream in humans, at above 85% accuracy, ahead of the prevailing industry standard.

doi:10.1016/j.jconrel.2025.02.022

Comparison of macromolecule permeation through extracellular matrix and hyaluronic acid to inform in vitro testing of subcutaneous therapies

Javorovic, J., Hanafy, B.I., Franek, F., Vllasaliu, D.

RSC Pharmaceutics · 2(3), 624–629 · 2025

doi:10.1039/d4pm00271g

A microfluidic in vitro method predicting the fate of peptide drugs after subcutaneous administration

Wanselius, M., Abrahmsén-Alami, S., Hanafy, B.I., Mazza, M., Hansson, P.

International Journal of Pharmaceutics · 667, 124849 · 2024

doi:10.1016/j.ijpharm.2024.124849

Nanoceria Prevents Glucose-Induced Protein Glycation in Eye Lens Cells

Hanafy, B.I., Cave, G.W.V., Barnett, Y., Pierscionek, B.K.

Nanomaterials · 11(6), 1473 · 2021

doi:10.3390/nano11061473

Bioavailability of Methionine-Coated Zinc Nanoparticles as a Dietary Supplement Leads to Improved Performance and Bone Strength in Broiler Chicken Production

Alkhtib, A., Scholey, D., Carter, N., Cave, G.W.V., Hanafy, B.I., Kempster, S.R.J., Mekapothula, S., Roxborough, E.T., Burton, E.J.

Animals · 10(9), 1482 · 2020

doi:10.3390/ani10091482

Treatment of Human Lens Epithelium with High Levels of Nanoceria Leads to Reactive Oxygen Species Mediated Apoptosis

Hanafy, B.I., Cave, G.W.V., Barnett, Y., Pierscionek, B.

Molecules · 25(3), 441 · 2020

doi:10.3390/molecules25030441

Ethylene glycol coated nanoceria protects against oxidative stress in human lens epithelium

Hanafy, B.I., Cave, G.W.V., Barnett, Y., Pierscionek, B.

RSC Advances · 9(29), 16596–16605 · 2019

doi:10.1039/c9ra01252d